Thiazovivin is a compound which dramatically improves the survival of hESCs upon trypsinization. Thiazovivin dramatically improves the survival of hESCs upon trypsinization. In combination with ALK5 (TGFβ receptor) inhibitor SB-431542 and MEK inhibitor PD-0325901, thiazovivin promotes the transformation of fibroblasts into stem cells with a 200-fold efficiency over the classic method. [1]