产品报价：询价
更新时间：2010/9/19 11:25:36
产地：北京
品牌：
型号：E-304
厂商性质： 生产型,贸易型,
公司名称： 惠特比科技发展（北京）有限公司
惠特比 : () (010-65531399)
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His6-Ubiquitin Activating Enzyme (UBE1) Catalog #: E-304 His6-Ubiquitin Activating Enzyme (UBE1) Datasheet:
 304_His-hE1.pdf
Product Source:
human recombinant This enzyme is responsible for the first step in ubiquitin-protein isopeptide bond formation, by forming a high-energy thioester bond with ubiquitin. The ubiquitin is activated by first adenylating with ATP its C-terminal glycine residue (Gly76) and thereafter linking this residue to the side chains of a cysteine residue in UBE1, yielding an ubiquitin-UBE1 thiolester and free AMP and PPi. The activated ubiquitin is then transferred to a lysine of the targeted protein via the E2-E3 conjugation cascade. UBE1 is a critical component for the initiation of any in vitro conjugation reactions. Protein has a tag at the N-terminus.
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