KMP2281-重组人TNFSF14/CD258蛋白|重组人肿瘤坏死因子配体超家族成员 14蛋白

产品标题：KMP2281-重组人TNFSF14/CD258蛋白|重组人肿瘤坏死因子配体超家族成员 14蛋白

产品编号: KMP2281

产品名称: Human CD258 Protein, mFc Tag

中文名称: 重组人TNFSF14/CD258蛋白

中文全称: 重组人肿瘤坏死因子配体超家族成员 14蛋白

关键词: 肿瘤坏死因子配体超家族成员 14, Tumor necrosis factor ligand superfamily member 14, Herpes virus entry mediator ligand, TNFSF14, HVEM-L, LIGHT, Human CD258 Protein, mFc Tag, Recombinant Protein, KMP2281

KMP2281-重组人TNFSF14/CD258蛋白|重组人肿瘤坏死因子配体超家族成员 14蛋白

物种: Human

宿主: HEK293 Cells

规格: 50ug, 100ug, 200ug

纯化方式: Affinity purification

纯度: >95% as determined by SDS-PAGE

内毒素水平: <1.0 EU/ug determined by the LAL method

缓冲液: PBS, pH7.4

Uniprot: O43557

SDS-PAGE: 

功能: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM (PubMed:9462508, PubMed:10754304).

Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (PubMed:10754304).

产品背景: Human TNFSF14 Protein, also known as LIGHT, belongs to a member of the tumor necrosis factor(TNF) ligand family. It can bind to NFRSF3/LTBR. It is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and it is also known as a herpesvirus entry mediator ligand(HVEML). TNFSF14 encodes a protein with a 37 aa cytoplasmic domain, 21aa transmembrane domain and 182 aa extracellular region. The gene is predominantly expressed in the spleen and also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines. TNFSF14 protein was found to probably function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. Studies have shown that this protein can prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.

保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.

运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.

说明: This product is for research use only.

官网链接: https://www.kmdbioscience.cn/

参考文献: 1.J. Immunol. 164:4105-4110 (2000)          

2.Immunity 8:21-30 (1998)

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