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KMP2280-重组人ILT3蛋白|LILRB4|CD58k
江志华 : (13116038708) (400-621-6806/022-82164980)
(联系我时,请说明是在来宝网上看到的,谢谢!)江志华 : (13116038708) (400-621-6806/022-82164980)
(联系我时,请说明是在来宝网上看到的,谢谢!)产品标题:KMP2280-重组人ILT3蛋白|LILRB4|CD58k
产品编号: KMP2280
产品名称: Human ILT3 Protein, His Tag
中文名称: 重组人 ILT3蛋白
中文全称: 重组人白细胞免疫球蛋白样受体 B 亚家族成员 4蛋白
关键词: 白细胞免疫球蛋白样受体 B 亚家族成员 4, Leukocyte immunoglobulin-like receptor subfamily B member 4, Mast cell surface glycoprotein Gp49B, CD85k, Lilrb4, Gp49b, Human ILT3 Protein, His Tag, Recombinant Protein, KMP2280
KMP2280-重组人ILT3蛋白|LILRB4|CD58k
物种: Human
宿主: HEK293 Cells
规格: 50ug, 100ug, 200ug
纯化方式: Affinity purification
纯度: >95% as determined by SDS-PAGE
内毒素水平: <1.0 EU/ug determined by the LAL method
缓冲液: PBS, pH7.4
Uniprot: A0A0A0MS20#structure
SDS-PAGE: KMP2280 SDS-PAGE image1.png
功能:
产品背景: Mouse Leukocyte Immunoglobulin-like Receptor Subfamily B Member 4(LILRB4/CD85k/ILT3) is an approximately transmembrane glycoprotein that negatively regulates immune cell activation. Mouse LILRB4 consists of a 215 amino acid(aa) extracellular domain with two Ig-like domains, a 22 aa transmembrane segment, and a 75 aa cytoplasmic domain with 3 immunoreceptor tyrosine-based inhibitory motifs(ITIM). Within the ECD, mouse LILRB4 shares 45% and 77% aa sequence identity with human and rat LILRB4, respectively. Alternative splicing of mouse LILRB4 generates a potentially soluble isoform that lacks the transmembrane segment. LILRB4 are expressed on dendritic cells(DC), monocytes, macrophages, and vascular endothelial cells(EC). Ligation of LILRB4 triggers ITIM-mediated inhibition of cellactivating signaling, leading to enhanced immune tolerance and reduced allogeneic graft rejection. Soluble LILRB4 induces the differentiation of CD8+ T suppressor cells(Ts) that can inhibit the effector functions of CD4+ Th cells and CD8+ CTL. In turn, CD8+ Ts cells induce LILRB4 up-regulation and a tolerogenic phenotype in monocytes, DC, and EC.
保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
说明: This product is for research use only.
官网链接: https://www.kmdbioscience.cn/
参考文献:
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