KMP2280-重组人ILT3蛋白|LILRB4|CD58k

产品标题：KMP2280-重组人ILT3蛋白|LILRB4|CD58k

产品编号: KMP2280

产品名称: Human ILT3 Protein, His Tag

中文名称: 重组人 ILT3蛋白

中文全称: 重组人白细胞免疫球蛋白样受体 B 亚家族成员 4蛋白

关键词: 白细胞免疫球蛋白样受体 B 亚家族成员 4, Leukocyte immunoglobulin-like receptor subfamily B member 4, Mast cell surface glycoprotein Gp49B, CD85k, Lilrb4, Gp49b, Human ILT3 Protein, His Tag, Recombinant Protein, KMP2280

KMP2280-重组人ILT3蛋白|LILRB4|CD58k

物种: Human

宿主: HEK293 Cells

规格: 50ug, 100ug, 200ug

纯化方式: Affinity purification

纯度: >95% as determined by SDS-PAGE

内毒素水平: <1.0 EU/ug determined by the LAL method

缓冲液: PBS, pH7.4

Uniprot: A0A0A0MS20#structure

SDS-PAGE: KMP2280 SDS-PAGE image1.png

功能: 

产品背景: Mouse Leukocyte Immunoglobulin-like Receptor Subfamily B Member 4(LILRB4/CD85k/ILT3) is an approximately transmembrane glycoprotein that negatively regulates immune cell activation. Mouse LILRB4 consists of a 215 amino acid(aa) extracellular domain with two Ig-like domains, a 22 aa transmembrane segment, and a 75 aa cytoplasmic domain with 3 immunoreceptor tyrosine-based inhibitory motifs(ITIM). Within the ECD, mouse LILRB4 shares 45% and 77% aa sequence identity with human and rat LILRB4, respectively. Alternative splicing of mouse LILRB4 generates a potentially soluble isoform that lacks the transmembrane segment. LILRB4 are expressed on dendritic cells(DC), monocytes, macrophages, and vascular endothelial cells(EC). Ligation of LILRB4 triggers ITIM-mediated inhibition of cellactivating signaling, leading to enhanced immune tolerance and reduced allogeneic graft rejection. Soluble LILRB4 induces the differentiation of CD8+ T suppressor cells(Ts) that can inhibit the effector functions of CD4+ Th cells and CD8+ CTL. In turn, CD8+ Ts cells induce LILRB4 up-regulation and a tolerogenic phenotype in monocytes, DC, and EC.

保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.

运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.

说明: This product is for research use only.

官网链接: https://www.kmdbioscience.cn/

参考文献: 

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