KMP2278-重组人 ILT3蛋白|重组人白细胞免疫球蛋白样受体 B 亚家族成员 4蛋白

产品标题：KMP2278-重组人 ILT3蛋白|重组人白细胞免疫球蛋白样受体 B 亚家族成员 4蛋白

产品编号: KMP2278

产品名称: Human ILT3 Protein, Fc Tag

中文名称: 重组人 ILT3蛋白

中文全称: 重组人白细胞免疫球蛋白样受体 B 亚家族成员 4蛋白

关键词: 白细胞免疫球蛋白样受体 B 亚家族成员 4, Leukocyte immunoglobulin-like receptor subfamily B member 4, Mast cell surface glycoprotein Gp49B, CD85k, Lilrb4, Gp49b, Human ILT3 Protein, Fc Tag, Recombinant Protein, KMP2278

KMP2278-重组人 ILT3蛋白|重组人白细胞免疫球蛋白样受体 B 亚家族成员 4蛋白

物种: Human

宿主: HEK293 Cells

规格: 50ug, 100ug, 200ug

纯化方式: Affinity purification

纯度: >90% as determined by SDS-PAGE

内毒素水平: <1.0 EU/ug determined by the LAL method

缓冲液: PBS, pH7.4

Uniprot: Q8NHJ6

SDS-PAGE: KMP2278 SDS-PAGE image1.png

功能: Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed:11875462).

Receptor for FN1 (PubMed:34089617).

Receptor for apolipoprotein APOE (PubMed:30333625).

Receptor for ALCAM/CD166 (PubMed:29263213).

Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:9151699).

Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production (PubMed:19833736).

This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed:34089617).

Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells (PubMed:16493035, PubMed:19833736, PubMed:29263213).

Induces up-regulation of CD86 on dendritic cells (PubMed:19860908).

Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation (PubMed:11875462).

Activated by APOE on acute myeloid leukemia (AML) cells which leads to suppression of T cell proliferation and promotion of AML cell migration and infiltration (PubMed:30333625).

LILRB4 signaling on AML cells is mediated by PTPN11/SHP-2 (PubMed:30333625).

产品背景: Mouse Leukocyte Immunoglobulin-like Receptor Subfamily B Member 4(LILRB4/CD85k/ILT3) is an approximately transmembrane glycoprotein that negatively regulates immune cell activation. Mouse LILRB4 consists of a 215 amino acid(aa) extracellular domain with two Ig-like domains, a 22 aa transmembrane segment, and a 75 aa cytoplasmic domain with 3 immunoreceptor tyrosine-based inhibitory motifs(ITIM). Within the ECD, mouse LILRB4 shares 45% and 77% aa sequence identity with human and rat LILRB4, respectively. Alternative splicing of mouse LILRB4 generates a potentially soluble isoform that lacks the transmembrane segment. LILRB4 are expressed on dendritic cells(DC), monocytes, macrophages, and vascular endothelial cells(EC). Ligation of LILRB4 triggers ITIM-mediated inhibition of cellactivating signaling, leading to enhanced immune tolerance and reduced allogeneic graft rejection. Soluble LILRB4 induces the differentiation of CD8+ T suppressor cells(Ts) that can inhibit the effector functions of CD4+ Th cells and CD8+ CTL. In turn, CD8+ Ts cells induce LILRB4 up-regulation and a tolerogenic phenotype in monocytes, DC, and EC.

保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.

运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.

说明: This product is for research use only.

官网链接: https://www.kmdbioscience.cn/

参考文献: 1.Nat. Immunol. 3:237-243 (2002)

2.J. Immunol. 176:2790-2798 (2006)

3.J. Biol. Chem. 284:34839-34848 (2009)

4.BMC Immunol. 10:56-56 (2009)

5.J. Immunol. 200:1207-1219 (2018)

6.Nature 562:605-609 (2018)

7.Int. Immunol. 33:447-458 (2021)

8.J. Exp. Med. 185:1743-1751 (1997)

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