KMP2277-重组人VSTM3蛋白|重组人具有免疫球蛋白和 ITIM 结构域的 T 细胞免疫受体蛋白

产品标题：KMP2277-重组人VSTM3蛋白|重组人具有免疫球蛋白和 ITIM 结构域的 T 细胞免疫受体蛋白

产品编号: KMP2277

产品名称: Human VSTM3 Protein, His Tag, Avi Tag

中文名称: 重组人VSTM3蛋白

中文全称: 重组人具有免疫球蛋白和 ITIM 结构域的 T 细胞免疫受体蛋白

关键词: 具有免疫球蛋白和 ITIM 结构域的 T 细胞免疫受体, T-cell immunoreceptor with Ig and ITIM domains,, VSIG9, VSTM3, TIGIT, V-set and transmembrane domain-containing protein 3, V-set and immunoglobulin domain-containing protein 9, Human VSTM3 Protein, His Tag, Avi Tag, Recombinant Protein, KMP2277

KMP2277-重组人VSTM3蛋白|重组人具有免疫球蛋白和 ITIM 结构域的 T 细胞免疫受体蛋白

物种: Human

宿主: HEK293 Cells

规格: 50ug, 100ug, 200ug

纯化方式: Affinity purification

纯度: >95% as determined by SDS-PAGE

内毒素水平: <1.0 EU/ug determined by the LAL method

缓冲液: PBS, pH7.4

Uniprot: Q495A1

SDS-PAGE: KMP2277 SDS-PAGE image1.png

功能: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

产品背景: T cell immunoreceptor with Ig and ITIM domains(TIGIT) is a member of the CD28 family within the Ig superfamily of proteins. TIGIT are expressed on NK cells and subsets of activated, memory and regulatory T cells, and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155 and Nectin-2 that appear on dendritic cells(DC) and endothelium. Ligation of TIGIT on T cell down-regulates TCR-mediated activation and subsequent proliferation, while NK cell TIGIT ligation blocks NK cell cytotoxicity. Through CD155 and Nectin-2, which also interact with DNAM-1/CD226 and CD96/Tactile, TIGIT is part of an interacting network of Ig superfamily members that may augment or oppose each other. In particular, TIGIT binding to CD155 can antagonize the effects of DNAM1.

保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.

运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.

说明: This product is for research use only.

官网链接: https://www.kmdbioscience.cn/

参考文献: Nat. Immunol. 10:48-57 (2009)

了解KMP2277-重组人VSTM3蛋白|重组人具有免疫球蛋白和 ITIM 结构域的 T 细胞免疫受体蛋白更多信息，可联系我们