KMP2272-重组人CD326蛋白|重组人上皮细胞粘附分子蛋白

产品标题：KMP2272-重组人CD326蛋白|重组人上皮细胞粘附分子蛋白

产品编号: KMP2272

产品名称: Human CD326 Protein, His Tag, Avi Tag

中文名称: 重组人CD326蛋白

中文全称: 重组人上皮细胞粘附分子蛋白

关键词: 上皮细胞粘附分子, Epithelial Cell Adhesion Molecule, Ep-CAM, Adenocarcinoma-Associated Antigen, Cell Surface Glycoprotein Trop-1, Epithelial Cell Surface Antigen, Epithelial Glycoprotein, EGP, Epithelial Glycoprotein 314, EGP314, hEGP314, KSA, Tumor-Associated Calcium Signal, Human CD326 Protein, His Tag, Avi Tag, Recombinant Protein, KMP2272

KMP2272-重组人CD326蛋白|重组人上皮细胞粘附分子蛋白

物种: Human

宿主: HEK293 Cells

规格: 50ug, 100ug, 200ug

纯化方式: Affinity purification

纯度: >95% as determined by SDS-PAGE

内毒素水平: <1.0 EU/ug determined by the LAL method

缓冲液: 20mM PB, 150mM NaCl, pH7.2

Uniprot: P16422

SDS-PAGE: KMP2272 SDS-PAGE image1.png

功能: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.

产品背景: Epithelial Cell Adhesion Molecule(EpCAM) is a signal type I transmembrane glycoprotein that belongs to the EPCAM family. EpCAM is composed of an extracellular domain with one thyroglobulin type-1 domain, a transmembrane domain and a cytoplasmic domain. EpCAM is found on the surface of adenocarcinoma, but not on mesodermal or neural cell membranes. The EpCAM molecule has been shown to function as a homophilic Ca2+ independent adhesion molecule. It may act as a physical homophilic interaction molecule between intestinal epithelial cells(IECs) and intraepithelial lymphocytes(IELs) at the mucosal epithelium as an immunological barrier providing the first line of defense against infection. Defects in EPCAM are a cause of hereditary non-polyposis colorectal cancer type 8(HNPCC8) and diarrhea type 5(DIAR5). EpCAM plays a role in embryonic stem cells proliferation and differentiation; it up-regulates the expression of FABP5, MYC and Cyclin A and Cyclin E. It is highly and selectively expressed by undifferentiated embryonic stem cells.

保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.

运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.

说明: This product is for research use only.

官网链接: https://www.kmdbioscience.cn/

参考文献: 1.Oncogene 23:5748-5758 (2004)

2.Cancer Lett. 225:151-157 (2005)

3.Stem Cells 28:29-35 (2010)

4.J. Biol. Chem. 285:8719-8732 (2010)

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