KMP2252-重组人CD272/BTLA蛋白|重组人B和T淋巴细胞衰减因子蛋白

产品标题：KMP2252-重组人CD272/BTLA蛋白|重组人B和T淋巴细胞衰减因子蛋白

产品编号: KMP2252

产品名称: Human CD272 Protein, mFc Tag

中文名称: 重组人CD272/BTLA蛋白

中文全称: 重组人B和T淋巴细胞衰减因子蛋白

关键词: B和T淋巴细胞衰减因子, B- and T-Lymphocyte Attenuator, B- and T-Lymphocyte-Associated Protein, CD272, BTLA, Human CD272 Protein, mFc Tag, Recombinant Protein, KMP2252

KMP2252-重组人CD272/BTLA蛋白|重组人B和T淋巴细胞衰减因子蛋白

物种: Human

宿主: HEK293 Cells

规格: 50ug, 100ug, 200ug

纯化方式: Affinity purification

纯度: >95% as determined by SDS-PAGE

内毒素水平: <1.0 EU/ug determined by the LAL method

缓冲液: PBS, pH7.4

Uniprot: Q7Z6A9

SDS-PAGE: KMP2252 SDS-PAGE image1.png

功能: 1.Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2.                    2.May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14.                                          3.In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells.

产品背景: B- and T-Lymphocyte Attenuator(BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type(immunoglobulin-like) domain. BTLA expression is induced during activation of T cells, and BTLA remain expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors(TNF-R), not just the B7 family of cell surface receptors. BTLA is a lymphocyte inhibitory receptor that inhibits lymphocytes during immune response. BTLA also is a ligand for tumor necrosis factor(receptor) superfamily, member 14(TNFRSF14), also known as herpes virus entry mediator(HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.

保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.

运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.

说明: This product is for research use only.

官网链接: https://www.kmdbioscience.cn/

参考文献: 1.Nat. Immunol. 4:670-679 (2003)                         

2.Biochem. Biophys. Res. Commun. 312:1236-1243 (2003)                                          

3.Nat. Immunol. 6:90-98 (2005)                                     

4.Nat. Immunol. 9:176-185 (2008)                                      

5.J. Immunol. 183:7286-7296 (2009)

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