BioDent使用设计独特的微探针在微米水平上对组织施压。探针处于一个小套管内部(图2 A)，套管可在组织上或组织内部建立参考点，然后便可测量软、硬材料和生物材料的凹陷距离、相对刚度和能量耗散，从而精确地检测材料力学性质(图2 B)。在恒力工作模式下，BioDent测量探针相对于参考点移动的距离，作为在此压力下材料发生的形变。在恒定距离工作模式（即将推出）下，BioDent测量使材料发生此种程度的形变时需要的力。

BioDent可临床测量材料性质作为健康或病变组织的指标。这些组织通常由不同的软硬组织在微米尺度上组合形成（图3），BioDent可在微米和毫米尺度上进行测量，以用于不同的生物材料。

 

 

 

 

  

 

 

 OsteoProbe? RUO是在体测量骨组织材料性质的唯一仪器，是实验室和临床研究中测量骨质量的有力工具。OsteoProbe? RUO是一种便携式单手操作微压痕仪，与测量骨密度的放射性方法（X射线、DXA和CT）具有不同的原理，它使用参考点压痕技术来检测材料对局部压力的抵抗性。

 

OsteoProbe? RUO使用特别设计的探针来进行皮下测量，无须切开组织。探针刺空软组织达到骨表面建立一个参考点，当探针受力达到一个预先设定的阈值后会自动触发更大的力进行测量。软件会记录下来凹陷深度和力之间的函数关系，然后用聚甲基丙烯酸甲酯作为参照材料进行校准来获得BMSi（材料强度指数）。

 

 英文介绍：

What is BioDent??

BioDent? is a bench-top Reference Point Indentation platform that enables scientists to easily measure the material properties of tissues and biomaterials. The in vitro to in vivo testing modes set BioDent? apart from other instruments, enabling the acquisition of previously impossible material property data that has clinical relevance – clinically measurable material properties.

While conventional material property testers have existed for decades and contribute valuable data to modern research, their testing methods cannot be translated  into the clinical setting – a requirement by many of today’s research funding sources.  BioDent? enables translational research of biomaterial and tissue material properties.

Click the video below for an introduction to BioDent? and the flagship bone testing applications. Don’t research bone? That’s OK.  Soft material applications are under development today.

Why Do I Need BioDent??

BioDent? will enable you to easily and directly obtain clinically measurable material properties of your tissues or biomaterials. It is generally understood that material properties are an important contributor to tissue and biomaterial health. However, no instruments have been available to easily measure these properties in the laboratory – often causing this important information to be excluded from research.  Also, no tools have previously been available to measure tissue material properties in vivo – resulting in frequent exclusion of their evaluation in life science research altogether.  BioDent? is the first and only solution for life science researchers to easily and directly obtain clinically measurable material properties.

How Does BioDent? Work?

BioDent? uses a microscopic wire test probe to push on a tissue or biomaterial at the micrometer level.  The test probe can be sheathed inside a small cannula reference probe which establishes a reference point on or in the sample.  In force-controlled mode, BioDent? measures the distance the test probe moves relative to the reference point as an indication of how much the material gave-way or flowed when pushed on at controlled force.  In distance-controlled mode (coming soon) BioDent? measures the force required to push a test probe a predetermined distance into the material, relative to the reference point.

Click here to learn how BioDent? works.

What Does BioDent? Tell Me?

BioDent? provides clinically measurable material properties as a potential signature of tissue health or disease. Hard and soft tissues are comprised of many material components that come together to form the tissue at the micrometer length scale. Depending on your setup, BioDent? can probe across the micrometer to millimeter length scale in order to provide a robust measure across all material components in the tissue or biomaterial.  BioDent? can also provide previously impossible direct, in vivo measures of material properties – clinically measurable material properties.

How Easy is it to Use BioDent??

Like every scientific instrument there is some training required before using BioDent?, however unlike many scientific instruments, no technical background is necessary.  ActiveLife Scientific provides all training material with the instrument, sufficient to get a non-technical scientist up and running in a few hours or less.  For Advanced Users, certain BioDent? configurations offer access to waveform control inputs and data analysis outputs through layered interfaces (coming soon).