LV1_prod 1 ml高剪切微流处理系统

Responding to customer demand, Microfluidics has launched the LV1 low volume benchtop machine, which brings high shear Microfluidizer processing capabilities to samples as small as 1 ml.

• Sample size: 1 ml to 6 ml per sample with operator settable volume control

• Shear rate: 12.25 million sec^-1 at 2069 bar (30,000 psi)

• Uniform particle size reduction and cell disruption

• Nanoemulsions, nanosuspensions, nanoencapsulation

Utilizing Microfluidics’ fixed-geometry interaction chamber technology, the LV1 is capable of processing a wide variety of fluids such as oil-in-water emulsions, solids-in-liquid suspensions, and cells, including the most difficult yeasts and plant cells, in as few as 1-2 passes. What’s more, the process is repeatable and is guaranteed to scale up to pilot and/or production volumes.

The LV1 benchtop was developed as a result of customer demand to bring   Microfluidizer quality nanotechnology processing to the milliliter scale with   applications in the pharmaceutical, biotechnology, chemical, nutraceutical/food,   cosmetic and energy industries:   ? Academic and commercial sectors  ? Drug discovery, Adme Tox, basic research and development   ? Proteomics and genomics applications  Microfluidizer processors offer exclusive benefits due to the fixed-geometry   interaction chamber and constant pressure pumping system. The unique   technology enables customers to achieve smaller sample sizes than other   methods with more uniform distribution and scaleup guaranteed.   With the LV1, researchers with limited resources and high value samples are able   to enhance their wide variety of applications and materials with benefits only a   Microfluidizer processor can provide:

Stable nanoemulsions  

? Highest protein recovery (typically >99% for E. coli after one pass)

? Challenging cell disruption (e.g. yeast, insect cells)  

? Improved bioavailability  

? Targeted delivery

? Nanoencapsulation (e.g. polymers, liposomes )

? Deagglomeration

Adding Value  For companies working with high value samples, it is imperative to minimize the   amount of product required for machine operation while maximizing recovery. In   addition to standard materials typically processed by our Microfluidizer processors,   the LV1 is also ideal for…

? Specialized cell lines for controlled disruption (e.g. mammalian and primary cell   lines)  

? Experimental API’s to enhance solubility when only a limited quantity is available.

LV1 Advantages

? Small sample size requirements   (1-6 ml)  

? Near total sample recovery  

? Easy clean up  

? No disassembly required  

? Quiet operation

Advantages of   All Microfluidizer   Processors  Product Quality

? 50% smaller particle size

? Narrowest particle size distribution

? Efficient cell disruption  

? Less protein damage  

? More stable emulsions

Process Enhancements

? Scaleup guaranteed

? Improved protein yield  

? Low or no heating with effective   cooling  

? Shorter and fewer process cycles  

? Media and chemical-free processing  

? Clean-in-Place and Steam-in-Place  

systems available in most cases