现货,Zibotentan,selleck,美国,ETA-receptor 抑制剂

Zibotentan (ZD4054)is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM). It was first evaluated as a potential treatment for pulmonary arterial hypertension in the late 1990s. Subsequently, interest switched to the role of endothelins in cancer, particularly hormone-resistant prostate cancer (HRPC).
In vitro, Zibotentan (ZD4054) has been shown to compete with 125I-ET-1 for binding to the cloned human ETA-receptor with an IC50 value of 21 nM. No binding to the ETB receptor was observed with concentrations of zibotentan in excess of 10 μM.
This agent is capable of inhibiting or reducing the multitude of effects that are evoked by ET-1 activation of the ETA receptor and which promote tumor survival, growth and progression. Zibotentan (ZD4054)treatment produced significant inhibition of tumor growth in ovarian and breast xenografts.^[1]

• The disposition and metabolism of zibotentan (ZD4054): an oral-specific endothelin A receptor antagonist in mice, rats and dogs. Clarkson-Jones JA et al. Xenobiotica. 2011 Sep;41(9):784-96.

特定的存储和包装每个产品的信息在产品说明书上都有注明 。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20 ° C ，抗体及蛋白等产品建议-60℃。抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。