现货，PHA-793887，selleck，美国进口，CDK 抑制剂

PHA-793887 is a novel pan-cdk inhibitor, including cdk1, cdk2, cdk4, cdk5, cdk7, and cdk9 with IC50 in the 5 to 140 nM range. [1]It is inactive against other 34 kinases representative of all kinase families, in particular c-abl, c-kit, lck, and TRKA with IC50＞10 mM. It shows anti-proliferative activity against several solid tumor cell lines, with IC50＜1 mM. In these cells, it is able to inhibit Rb phosphorylation and expression of S-phase cyclins, such as cyclin A. ^[1,2]

• Transcriptional Analysis of an E2F Gene Signature as a Inhibitor Biomarker of Activity of the Cyclin-Dependent Kinase PHA-793887 in Tumor and Skin Biopsies from a Phase I Clinical Study Roberta Bosotti, Marina Ciomei, et al. Mol Cancer Ther 2010;9:1265-1273
• Poly ADP ribose polymerase (PARP) inhibitors Rachele Alzani,Olga Pedrini,et al. Experimental Hematology 2010 ;38:259–269

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