产品报价：3213元
更新时间：2012/7/26 10:28:52
产地：美国
品牌：selleck
型号：CAS号: 677297-51-7
厂商性质： 生产型,贸易型,
公司名称： 赛导通生物科技（广州）有限公司
潘贺华 : (13926198506) (400-168-1698)
（联系我时，请说明是在来宝网上看到的，谢谢！）| 分子量(MW): | 346.34 |  |
|---|---|---|
| 化学式: |
C18H14N6O2 |
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| 溶解度: | DMSO ≥9mg/mL Water <1mg/mL Ethanol <1mg/mL | |
| 纯度: | >99% | |
| 稳定性: | at -20℃ 2 years | |
| CAS号: | 677297-51-7 |
TG100-115, inhibited PI3K γ and -δ(IC50 values of 83 and 235 nM, respectively), whereas both PI3Kα and -β were relatively unaffected (IC50 values>1 μM). As a gauge of general specificity, TG100-115 was also assayed against a 133 protein kinase panel, none of which was inhibited at IC50 values <1 μM. [ 2,3]
TG100-115 is applied to anti-inflammatory therapy for respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). TG100-115 could reduce inflammation and mucin accumulation.
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We treated all of drugs in T47D which has a PI3KCA H1044R mutation with the concentration shown below for 1 hour and performed western blot analysis using antibodies to phospho-AKT(SERINE 472), and total AKT.
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