产品报价：询价
更新时间：2012/7/26 10:41:47
产地：美国
品牌：selleck
型号：CAS号: 284028-89-3
厂商性质： 生产型,贸易型,
公司名称： 赛导通生物科技（广州）有限公司
潘贺华 : (13926198506) (400-168-1698)
（联系我时，请说明是在来宝网上看到的，谢谢！）| 分子量(MW): | 312.31 |  |
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| 化学式: |
C14H11F3N2OS |
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| 溶解度: | DMSO ≥3mg/mL Water <1mg/mL Ethanol ≥5mg/mL | |
| 纯度: | >99% | |
| 稳定性: | at -20℃ 2 years | |
| CAS号: | 284028-89-3 |
XAV 939 is a small molecule and selective Wnt pathway transcription factor β-catenin-mediated transcription inhibitor and axin stabilizing agent with IC50 of 11 and 4nM for the inhibition of TNKS1 and TNKS2, respectively. It stimulates beta-catenin degradation by stabilizing axin, the concentration-limiting component of the destruction complex and stabilizes axin by inhibiting the poly-ADP-ribosylating enzymes tankyrase 1 and tankyrase 2. Both tankyrase isoforms interact with a highly conserved domain of axin and stimulate its degradation through the ubiquitin-proteasome pathway. Deregulated Wnt/b-catenin pathway activity has been implicated in many cancers. [1]
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cells plated at 2 x 10E4 in 24 multiwell with DMEM 10% FBS preconditioning 24 hrs (pretreatment withour wnt) switch medium from 2% HS + WNT 100 ng/ml |
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