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抗体信息如下：

Primary Antibodies

Bid Antibody

Background

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death (reviewed in 2 and 3). Bid, a pro-apoptotic Bcl-2 family member, is cleaved by caspase-8 in response to apoptotic signals (4,5), exposing the Bcl-2 homology 3 (BH3) domain which is normally buried in the full-length protein (6). The cleaved complex is myris-toylated and translocated to the mitochondrial membrane where it may induce mitochondrial Bax and Bak to oligomerize (7,8).

Additional Names

Bid (CT), Bid

	Description Left: Western blot analysis of Bid in mouse lung cell lysates with Bid antibody at (A) 0.5, (B) 1, and (C) 2 μg/ml. Below: Immunohistochemical staining of mouse lung tissue using Bid antibody at 2 μg/ml.
	Other Product Images

Source

Bid antibody was raised against a peptide corresponding to 14 amino acids near the carboxy-terminus of human Bid.

Purification

Ion exchange chromatography purified

Clonality / Clone

This is a polyclonal antibody.

Host

Bid antibody was raised in rabbit.

Please use anti-rabbit secondary antibodies.

Immunogen

Human Bid (C-Terminus) Peptide (Cat. No. 3353P)

Application

Bid antibody can be used for detection of Bid by Western blot at 0.5 to 1 μg/ml.

Tested Application

E, WB, IHC

Buffer

Antibody is supplied in PBS containing 0.02% sodium azide.

Blocking Peptide

Cat. No. 3353P - Bid Peptide

Storage

Bid antibody can be stored at 4?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Positive Control

1. Cat. No. 1402 - Mouse Lung Tissue Lysate

Species Reactivity

H, M

Protein GI Number

54673639

Protein Accession Number

AAH36364

Short Description

(CT) a member of the bcl-2 family

This product belongs to the following categories:

• Antibodies
• Polyclonal Antibodies
• Apoptosis Antibodies
• Cancer Antibodies

Related Products

• Bak Antibody
  (Catalog No. 3347).
• Bax Antibody
  (Catalog No. 3351).
• Bcl-2 Antibody
  (Catalog No. 3335).
• Bid Antibody
  (Catalog No. 3355).
• BID Antibody
  (Catalog No. 45-021).
• Bid Peptide
  (Catalog No. 3353P).
• Lung Lysate
  (Catalog No. 1402).
• Multiple Species Tissue Array - Lung Tissue
  (Catalog No. 10-100-MSTA).

References

1. Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7.
2. Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003; 22:8590-607.
3. Heiser D, Labi V, Erlacher M, et al. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp. Geron. 2004; 39:1125-35.
4. Wang K, Yin XM, Chao DT, et al. BID: a novel BH3 domain-only death agonist. Genes Dev. 1996; 10:2859-69.

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