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抗体信息如下：

Primary Antibodies

Bcl-B Antibody

Background

Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-B is a recently discovered anti-apoptotic member of the Bcl-2. Unlike the mouse homolog (also known as Diva/Boo) which is predominantly expressed in ovary and testis, the human Bcl-B protein is widely expressed. Also, the human Bcl-B functions by binding to and suppressing the apoptotic activity of Bax, whereas the mouse homolog binds Bak and also interacts with the apoptosis protein Apaf-1. Despite its predicted molecular weight, Bcl-B is often at higher molecular weights, presumably due to post-translational modifications.

Additional Names

Bcl-B, Boo, Diva, Nrh

	Description Left: Western blot analysis of Bcl-B in Jurkat lysate with Bcl-B antibody at 1 礸/ml in the (A) absence and (B) presence of blocking peptide. Below: Immunocytochemistry of Bcl-B in Jurkat cells with Bcl-B antibody at 10 μg/ml.
	Other Product Images

Source

Bcl-B antibody was raised against a 16 amino acid peptide from near the amino terminus of human Bcl-B.

Purification

Affinity chromatography purified via peptide column

Clonality / Clone

This is a polyclonal antibody.

Host

Bcl-B antibody was raised in rabbit.

Please use anti-rabbit secondary antibodies.

Application

Bcl-B antibody can be used for the detection of Bcl-B by Western blot at 1 - 2 μg/ml.

Tested Application

E, WB, ICC

Buffer

Antibody is supplied in PBS containing 0.02% sodium azide.

Blocking Peptide

Cat.No. 3163P - Bcl-B Peptide

Storage

Bcl-B antibody can be stored at 4?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Positive Control

1. Cat. No. 1205 - Jurkat Cell Lysate

Species Reactivity

H

Protein GI Number

9966783

Protein Accession Number

NP_065129

Short Description

an anti-apoptotic member of the Bcl-2 family

This product belongs to the following categories:

• Antibodies
• Polyclonal Antibodies
• Apoptosis Antibodies

Related Products

• Apaf1 Antibody
  (Catalog No. 2015).
• Bak Antibody
  (Catalog No. 3347).
• Bax Antibody
  (Catalog No. 3351).
• Bcl-2 Antibody
  (Catalog No. 3335).
• Bcl-B Peptide
  (Catalog No. 3163P).
• Jurkat Cell Slide
  (Catalog No. 17-005).
• Jurkat Lysate
  (Catalog No. 1205).

References

1. Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003; 22:8590-607
2. Heiser D, Labi V, Erlacher M, et al. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp. Geron. 2004; 39:1125-35.
3. Ke N, Godzik A, and Reed JC. Bcl-B: A novel Bcl-2 family member that differentially binds and regulates Bax and Bak. J. Biol. Chem. 2001; 276:12481-4.
4. Song Q, Kuang Y, Dixit VM, et al. Boo, a negative regulator of cell death, interacts with Apaf-1. EMBO J. 1999; 18:167-78

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