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抗体信息如下：

Primary Antibodies

Caspase-14 Antibody

Background

Caspases are a family of cysteine proteases that can be divided into apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1b and IL-18. Caspase-14 is highly expressed in embryonic but not adult tissues. It is processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in the keratinocyte terminal differentiation, which is important for the formation of the skin barrier.

Additional Names

Caspase-14, Mini-interleukin-1 converting enzyme, Mini-ICE, MICE

	Description Left: Western blot analysis of caspase-14 in Jurkat cell lysate in the (A) absence or (B) presence of blocking peptide with caspase-14 antibody at 1 μg/ml. Below: Immunohistochemistry of caspase-14 in human liver tissue with caspase-14 antibody at 2.5 μg/ml.
	Other Product Images

Source

Caspase-14 antibody was raised against a 16 amino acid peptide from near the carboxy-terminus of human caspase-14.

Purification

Affinity chromatography purified via peptide column

Clonality / Clone

This is a polyclonal antibody.

Host

Caspase-14 antibody was raised in rabbit.

Please use anti-rabbit secondary antibodies.

Application

Caspase-14 antibody can be used for the detection of caspase-14 by Western blot at 1 μg/ml.

Tested Application

E, WB, IHC

Buffer

Antibody is supplied in PBS containing 0.02% sodium azide.

Blocking Peptide

Cat.No. 2505P - Livin Peptide

Storage

Caspase-14 antibody can be stored at 4?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Positive Control

1. Cat. No. 1205 - Jurkat Cell Lysate
2. Cat. No. 1304 - Human Liver Tissue Lysate

Species Reactivity

H, M, R

Protein GI Number

6753280

Protein Accession Number

NP_033939

Short Description

a novel caspase

This product belongs to the following categories:

• Antibodies
• Polyclonal Antibodies
• Apoptosis Antibodies

Related Products

• Caspase-14 Peptide
  (Catalog No. 2509P).
• Jurkat Cell Slide
  (Catalog No. 17-005).
• Jurkat Lysate
  (Catalog No. 1205).
• Liver Lysate
  (Catalog No. 1304).
• Liver Tissue Slide (Normal)
  (Catalog No. 10-201).

References

1. Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-74.
2. Zhivotovsky B and Orrenius S. Caspase-2 function in response to DNA damage. Biochim. Biophys. Res. Comm. 2005; 331:859-67.
3. Kuida K, Lippke JA, Ku G, et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 1995; 267:2000-3.
4. Gracie JA, Robertson SE, and McInnes IB. Interleukin-18. J. Leukoc. Biol. 2003; 73:213-224.

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