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抗体信息如下：

Primary Antibodies

APRIL Antibody

Background

Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF- and ApoL-related Leukocyte-expressed Ligand 2), and TRDL-1a (for TNF related death ligand 1a) in human and mouse (1-4). Two receptors for APRIL were recently identified and designated TACI and BCMA (5-7). APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-κB, and induces cell death (1-7). APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer (8,9).

Additional Names

APRIL (ED2)

	Description Left: Western blot analysis of APRIL expression in Jurkat cells with APRIL antibody at 1 μg/ml (A), 2 μg/ml (B), and 4 μg/ml (C). Below: Immunohistochemistry of APRIL in human prostate tissue with APRIL antibody at 10 μg/ml.
	Other Product Images

Source

APRIL antibody was raised against a synthetic peptide corresponding to amino acids within an extracellular domain of human APRIL.

Purification

Affinity chromatography purified via peptide column

Clonality / Clone

This is a polyclonal antibody.

Host

APRIL antibody was raised in rabbit.

Please use anti-rabbit secondary antibodies.

Immunogen

Human APRIL (Extracellular Domain 2) Peptide (Cat. No. 2415P)

Application

APRIL antibody can be used for detection of APRIL by Western blot at 1 ?4 μg/ml.Jurkat cell lysate was used as a positive control and a 27 kDa band was detected. APRIL antibody is human, mouse and rat reactive.

Tested Application

E, WB, IHC

Buffer

Antibody is supplied in PBS containing 0.02% sodium azide.

Blocking Peptide

Cat. No. 2415P - APRIL (ED2) Peptide

Storage

APRIL antibody can be stored at 4?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Positive Control

1. Cat. No. 1205 - Jurkat Cell Lysate
2. Cat. No. 1312 - Human Prostate Tissue Lysate

Species Reactivity

H, M

Protein GI Number

4507599

Protein Accession Number

NP_003799

Short Description

(ED2) A new member in the TNF family

This product belongs to the following categories:

• Antibodies
• Polyclonal Antibodies
• Cytokine Antibodies
• Cancer Antibodies

Related Products

• APRIL (MAb Aprily-1) Antibody
  (Catalog No. XA-1019).
• APRIL (MAb Aprily-8) Antibody
  (Catalog No. XA-1020).
• APRIL (MAb Sacha-1) Antibody
  (Catalog No. XA-1014).
• APRIL (MAb Sacha-2) Antibody
  (Catalog No. XA-1025).
• APRIL Antibody
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• APRIL Antibody
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• APRIL Antibody
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• APRIL Antibody
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• APRIL Peptide
  (Catalog No. 2415P).
• BAFF and Receptor Detection Set
  (Catalog No. PSI-1803).
• BAFF Receptor Antibody
  (Catalog No. 3097).
• Jurkat Cell Slide
  (Catalog No. 17-005).
• Jurkat Lysate
  (Catalog No. 1205).
• Prostate Lysate
  (Catalog No. 1312).

References

1. Hahne M, Kataoka T, Schroter M, et al. APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. J Exp Med. 1998;188(6):1185-90.
2. Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J Leukoc Biol. 1999;65(5):680-3.
3. Kelly K, Manos E, Jensen G, et al. APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death. Cancer Res. 2000;60(4):1021-7.
4. Yu G, Boone T, Delaney J, et al. APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Nat Immunol. 2000;1(3):252-6.

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