Features and Benefits

? Deconjugate and detect both glucuronides and sulfate esters.
? Quickly screen for steroids, benzodiazepines, cannabinoids, opioids, and other drugs.

    Principle

Glucuronidation is one of the basic principles of metabolism. Most substances presented to the human body undergo metabolic processing that includes conjugation with glucuronic acid by UDP-glucuronosyltransferases (UGTs). This enzyme catalyzes the transfer of a glucuronyl group to many biological and pharmacologically active endogenous and exogenous molecules. Glucuronide is in general more soluble, less toxic, and more easily excreted by the human body compared to the original molecule.
In addition, sulfation of the drug or chemical substance by sulfotransferases in the human body may occur. Sulfation in general, is less predictable than glucuronidation since many isoenzymes of sulfotransferases exist, and there are individual differences in the ratio of glucuronidation versus sulfation of the substance.

产品描述

Working concentration: In many applications the product can be diluted with water immediately before use or employed undiluted.
Note: The present β-glucuronidase/arylsulfa

tase preparation is very concentrated and must be diluted for some applications. Moreover, in the preparation of protoplasts, the precise concentration to use for a given strain of yeast must be found empirically.
Storage conditions (working solution): Note: Aliquot portions of the diluted preparation may be stored at -15 to -25 °C; they should not be thawed and refrozen more than a time or two, and storage at the lower temperature does not lengthen their life beyond that of the product kept at 2 to 8 °C.

pecificity

 β-Glucuronidase/Arylsulfatase shows a broad specificity for many kinds of β-glucuronides and sulfate esters.

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