艾美捷Polymer Source高质量研究级聚合物方案

艾美捷Polymer Source高质量研究级聚合物方案

艾美捷Polymer Source 专注于高质量研究级聚合物。凭借在定制聚合物业务方面超过25年的成功经验，Polymer Source在提供高质量研究级聚合物方面处于比较前端的地位。

Polymer Source主要重点是创新和开发针对简单和复杂大分子结构的巧妙方法，为学术界和工业界的研发团体提供聚合物的极其重要的任务。

Polymer Source热门研究： 

Poly(acrylamide) 9003-05-8

Poly(2,6-dimethyl-1,4-phenylene oxide) 25134-01-4

Poly(methacrylic acid), isotactic 25087-26-7

Poly(4-vinyl pyridine, quaternized with methyl iodide) 25232-41-1

Poly(glycidyl methacrylate) 25067-05-4

Poly(4-tert-butyl styrene)  26009-55-2

6-(4'-Cyanobiphenyl-4-yloxy)-hexyl methacrylate 117318-91-9

Di(N-succinimidyl) glutarate 79642-50-5

Polystyrene, certified reference material (PS standards kit) 9003-53-6

Triethyl((1-methoxy-2-methyl-2- propenyl)oxy)-silane 135625-10-4

艾美捷科技是Polymer Source的中国代理商，为科研工作者提供优质的产品与服务。

来源：https://www.amyjet.com/brand/Polymer-Source.shtml

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艾美捷Polymer Source 特种聚合物之均聚物

艾美捷Polymer Source 特种聚合物包括均聚物、嵌段共聚物、无规和交替共聚物、星形聚合物、接枝共聚物（梳状和刷状聚合物）、蝌蚪形聚合物、功能化聚合物、标记聚合物、导电和发光聚合物、电子级聚合物、无机聚合物。

那么接下来一起看看Polymer Source的均聚物。

均聚物，是只由一种单体聚合而成的聚合物。如聚氯乙烯和聚苯乙烯，它们的重复单元分别是各自的结构单元，即可用重复单元表示高分子结构。

Polymer Source 均聚物包括以下几种：

1.亲水性聚合物

2.疏水性聚合物

3.两性离子均聚物

Polymer Source亲水性聚合物

1聚丙烯酰胺家族

2聚（[烷基]丙烯酸）和聚（[甲基]丙烯酸）家族

3聚乙二醇或聚环氧乙烷

4聚苯乙烯磺酸及其盐

5聚乙烯酰胺和聚乙烯胺家族

6聚（乙烯基锌）

7聚（N-乙烯基咪唑，季铵化）

8聚（乙烯基吡啶，季铵化）

9其他亲水性聚合物

Polymer Source疏水性聚合物

1聚（[烷基]丙烯酸酯）和聚（[烷基]甲基丙烯酸酯）家族

2聚二烯家族

3聚咪唑家族

4聚丙交酯和聚内酯家族

5聚烯烃家族

6聚环氧乙烷家族

7聚吡啶家族

8聚硅氧烷家族

9聚苯乙烯家族

10聚乙烯蒽/菲/联苯家族

11聚乙烯基萘家族

12其他疏水均聚物

Polymer Source两性离子均聚物

1聚羧基甜菜碱丙烯酰胺

2聚羧基甜菜碱甲基丙烯酸酯

3聚（羧基甜菜碱甲基丙烯酸酯），α-N-羟基琥珀酰基封端

4聚（2-叔丁氧基-N-（2-（甲基丙烯酰氧基）乙基）-N，N-二甲基-2-氧代乙胺）， α-N-羟基琥珀酰基封端

艾美捷科技是Polymer Source的中国代理商，为科研工作者提供优质的产品与服务。

来源：https://www.amyjet.com/brand/Polymer-Source.shtml

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艾美捷PolySciTech PLGA-CY5说明书

艾美捷PLGA-CY5聚丙交酯-共乙交酯-氰基5相关参数：

中文名称：PLGA-CY5 / 聚（丙交酯-共-乙交酯）-花青 5, Mn 30,000-55,000 Da, 50:50 LA:GA

英文名字：PLGA-CY5 / Poly(lactide-co-glycolide)-Cyanine 5, Mn 30,000-55,000 Da, 50:50 LA:GA

cat#PST-AV034

规格：100mg

PLGA-CY5图例：

图：H-NMR Spectrum of copolymers in CDCl3 (Bruker ≥300 MHz, PINMRF) NMR of PLGA copolymer: LA-GA =48%-52% molar ratio (LA:GA 53%:47% Da) 共聚物在CDCl3（Bruker≥300MHz，PINMRF）PLGA共聚物的NMR：LA-GA=48%-52%摩尔比率（LA:GA 53%：47%Da）

PLGA-CY5相关文献：

Granot, Z., Völs, S., Kaisar-Iluz, N., Shaul, M.E., Ryvkin, A., Ashkenazy, H., Yehuda, A., Atamneh, R., Meital, B.D.N., Nadav, M. and Hirsch, S.. "Targeted Nanoparticles Modify Neutrophil Function In Vivo". Frontiers in Immunology p.5679.

Product Used: AV034, AI110

Product Usage: Decorated Nanoparticle Shell

Hirsch, S., Hinden, L., Naim, M.B.D., Baraghithy, S., Permyakova, A., Azar, S., Nasser, T., Portnoy, E., Agbaria, M., Nemirovski, A. and Golomb, G.. "Hepatic targeting of the centrally active cannabinoid 1 receptor (CB1R) blocker rimonabant via PLGA nanoparticles for treating fatty liver disease and diabetes". Journal of Controlled Release 353, pp.254-269.

Product Used: AV034

Product Usage: Nanoparticle Shell

Lamson, Nicholas G., Andrew J. Pickering, Jeffrey Wyckoff, Priya Ganesh, Joelle P. Straehla, and Paula T. Hammond. "Core material and surface chemistry of Layer-by-Layer (LbL) nanoparticles independently direct uptake, transport, and trafficking in preclinical blood-brain barrier (BBB) models". bioRxiv (2022)

Product Used: AV034

Product Usage: Nanoparticle Shell

Piotrowski-Daspit, A.S., Barone, C., Lin, C.Y., Deng, Y., Wu, D., Binns, T.C., Xu, E., Ricciardi, A.S., Putman, R., Garrison, A. and Nguyen, R.. "In vivo correction of cystic fibrosis mediated by PNA nanoparticles". Science Advances 8(40), p.eabo0522.

Product Used: AV034

Product Usage: Nanoparticle Shell

Stigliano, Cinzia, Allison Frazier, and Philip J. Horner. "Modulation of Neuroinflammation Via Selective Nanoparticle‐Mediated Drug Delivery to Activated Microglia/Macrophages in Spinal Cord Injury". Advanced Therapeutics 2200083

Product Used: AV034

Product Usage: Nanoparticle Shell

来源：https://www.amyjet.com/products/PST-AV034.shtml

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艾美捷PolySciTech PLGA聚(丙交酯-共-乙交酯)说明书

艾美捷PLGA聚(丙交酯-共-乙交酯)相关参数：

中文名称：PLGA / 聚（丙交酯-共-乙交酯），LG 50:50 酸封端（Mn 45,000-55,000 Da）

英文名字：PLGA / Poly(lactide-co-glycolide), LG 50:50acid endcap (Mn 45,000-55,000 Da)

cat#PST-AP059

PLGA聚(丙交酯-共-乙交酯)图例：

图1：FTIR分析：从KBr盐板上的流延膜收集放置在Nicollet Avatar 320光谱仪中传输模式。 

图2：GPC分析方法：Waters Breeze 2系统，THF流量为1ml/min，流经三个GPC柱。通过折射检测根据聚苯乙烯标准校准。

PLGA聚(丙交酯-共-乙交酯)部分文献参考：

Hwang, ChaeRim, Song Yi Lee, Han-Jun Kim, KangJu Lee, Junmin Lee, Dae-Duk Kim, and Hyun-Jong Cho. "Polypseudorotaxane and polydopamine linkage-based hyaluronic acid hydrogel network with a single syringe injection for sustained drug delivery". Carbohydrate Polymers (2021): 118104.

Product Used: AP059

Product Usage: Microparticle

Joseph, Andrea, Georges Motchoffo Simo, Torahito Gao, Norah Alhindi, Nuo Xu, Daniel J. Graham, Lara J. Gamble, and Elizabeth Nance. "Surfactants influence polymer nanoparticle fate within the brain". Biomaterials (2021): 121086

Product Used: AK106, AP059

Product Usage: Nanoparticle Shell

Lee, Song Yi, Ju-Hwan Park, Mingyu Yang, Min-Jun Baek, Min-Hwan Kim, Junmin Lee, Ali Khademhosseini, Dae-Duk Kim, and Hyun-Jong Cho. "Ferrous sulfate-directed dual-cross-linked hyaluronic acid hydrogels with long-term delivery of donepezil". International Journal of Pharmaceutics (2020): 119309.

Product Used: AP059

Product Usage: Microparticle

Lee, Song Yi, Suyeong Nam, Ja Seong Koo, Sungyun Kim, Mingyu Yang, Da In Jeong, ChaeRim Hwang, JiHye Park, and Hyun-Jong Cho. "Possible contribution of sialic acid to the enhanced tumor targeting efficiency of nanoparticles engineered with doxorubicin". Scientific Reports 10, no. 1 (2020): 1-15

Product Used: AP059

Product Usage: Nanoparticle Shell

Liao, Rick, Jessica Pon, Michael Chungyoun, and Elizabeth Nance. "Enzymatic protection and biocompatibility screening of enzyme-loaded polymeric nanoparticles for neurotherapeutic applications". Biomaterials 257 (2020): 120238

Product Used: AP059

Product Usage: Nanoparticle Shell

Seo, Ji-Hye, Song Yi Lee, Sungyun Kim, Mingyu Yang, Da In Jeong, ChaeRim Hwang, Min-Hwan Kim et al.. "Monopotassium phosphate-reinforced in situ forming injectable hyaluronic acid hydrogels for subcutaneous injection". International Journal of Biological Macromolecules (2020)

Product Used: AP059

Product Usage: Microparticle

来源：https://www.amyjet.com/products/PST-AP059.shtml

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艾美捷PolySciTech mPEG-PLGA说明书

艾美捷mPEG-PLGA相关参数：

中文名称：mPEG-PLGA / 甲氧基聚（乙二醇）-b-聚（丙交酯-共-乙交酯），（Mw ~5,000:20,000 Da）LA:GA 50:50

英文名字：mPEG-PLGA / Methoxy poly(ethylene glycol)-b-poly(lactide-co-glycolide), (Mw ~5,000:20,000 Da) LA:GA 50:50

cat#PST-AK037

mPEG-PLGA图例：

图：H-NMR Spectrum of copolymers in CDCl3 (Bruker ≥300 MHz, PINMRF) NMR of PLGA-PEG copolymer: EG/LA-GA =119/156-173 (Mn EG/LA:GA 5242*/11255:10021 Da)共聚物在CDCl3（Bruker≥300MHz，PLGA-PEG共聚物的PINMRF）NMR：EG/LA-GA=119/156-173（锰EG/LA:GA 5242*/11255:10021 Da）

mPEG-PLGA相关研究：

AV001   AK-PLGAFl-1 AV01

聚（丙交酯-共乙交酯）-荧光素聚

AV002   AK-PLGAFl-2 AV02

聚（丙交酯-共乙交酯）-荧光素聚

AV004   AK-PLGA-FL-4-B0 AV04

聚（丙交酯-共乙交酯）-荧光素聚

AV005   AK-PLLA-40k-Fl AV05

聚（L-丙交酯）-荧光素

AV006   AK-PLGA-30k-FPI749 AV06

聚（丙交酯-共乙交酯）-FPI749 PLGA-FPI749

AV008   AK-PLGA-20K-FPR648 AV08

聚（丙交酯-共乙交酯）-FPR648

AV011   聚（丙交酯-共乙克醇化物）-罗丹明 B PLGA

AV013   聚（L-乳酸）酸-FPR648

AV015   聚丙交酯-共乙交酯-火烈士福陆 FKR648 PLGA-FKR648

AV016   聚（D，L-丙交酯）-荧光素

AV017   甲氧基聚乙二醇-b-聚（D，L）乳酸-弗拉玛-福陆FKR648共聚物

AV018   甲氧基-聚乙二醇-b-聚（丙交酯-共乙交酯）-FKR560共聚物

AV019   甲氧基-聚乙二醇-b-聚（丙交酯-共乙醇化物）-FKB350共聚物

AV020   甲氧基-聚乙二醇-b-聚（丙交酯-共-乙交酯）-FKG456共聚物

AV021   甲氧基-聚乙二醇-b-聚（丙交酯-共乙交酯）-FKR560共聚物

AV022   聚（丙交酯-共乙交酯）-FKB350共聚物PLGA-FKB350

AV024   聚（D，L-乳酸）共聚物-FPR648

AV025   聚（丙交酯-共乙交酯）-b-聚乙二醇-b-聚（丙交酯-共乙交酯）

AV026   聚（丙交酯-共乙交酯）-b-聚乙二醇-b-聚（丙交酯-共乙交酯）

来源：https://www.amyjet.com/products/PST-AK037.shtml

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艾美捷PolySciTech mPEG-PLGA图例&文献参考

艾美捷mPEG-PDLLA相关参数：

中文名称：mPEG-PDLLA / 甲氧基聚（乙二醇）-b-聚（D,L-丙交酯），（Mw ~5,000:16,000 Da）

英文名字：mPEG-PDLLA / Methoxy poly(ethylene glycol)-b-poly(D,L-lactide), (Mw ~5,000:16,000 Da)

cat#：PST-AK054

mPEG-PDLLA图例：

图：H-NMR Spectrum of copolymers in CDCl3 (Varian Inova 500 MHz instrument) NMR of PLA-PEG-PLA repeat units: EG-LA =114-227(Mn EG-LA: 5022-16335)CDCl3（Varian Inova 500 MHz）中共聚物的H-NMR谱仪器）PLA-PEG-PLA重复单元的NMR：EG-LA=114-227（锰EG-LA:55022-16335）

mPEG-PDLLA文献参考：

Granot, Z., Völs, S., Kaisar-Iluz, N., Shaul, M.E., Ryvkin, A., Ashkenazy, H., Yehuda, A., Atamneh, R., Meital, B.D.N., Nadav, M. and Hirsch, S.. "Targeted Nanoparticles Modify Neutrophil Function In Vivo". Frontiers in Immunology p.5679.

Product Used: AV034, AI110

Product Usage: Decorated Nanoparticle Shell

Hirsch, S., Hinden, L., Naim, M.B.D., Baraghithy, S., Permyakova, A., Azar, S., Nasser, T., Portnoy, E., Agbaria, M., Nemirovski, A. and Golomb, G.. "Hepatic targeting of the centrally active cannabinoid 1 receptor (CB1R) blocker rimonabant via PLGA nanoparticles for treating fatty liver disease and diabetes". Journal of Controlled Release 353, pp.254-269.

Product Used: AV034

Product Usage: Nanoparticle Shell

Lamson, Nicholas G., Andrew J. Pickering, Jeffrey Wyckoff, Priya Ganesh, Joelle P. Straehla, and Paula T. Hammond. "Core material and surface chemistry of Layer-by-Layer (LbL) nanoparticles independently direct uptake, transport, and trafficking in preclinical blood-brain barrier (BBB) models". bioRxiv (2022)

Product Used: AV034

Product Usage: Nanoparticle Shell

Piotrowski-Daspit, A.S., Barone, C., Lin, C.Y., Deng, Y., Wu, D., Binns, T.C., Xu, E., Ricciardi, A.S., Putman, R., Garrison, A. and Nguyen, R.. "In vivo correction of cystic fibrosis mediated by PNA nanoparticles". Science Advances 8(40), p.eabo0522.

Product Used: AV034

Product Usage: Nanoparticle Shell

Stigliano, Cinzia, Allison Frazier, and Philip J. Horner. "Modulation of Neuroinflammation Via Selective Nanoparticle‐Mediated Drug Delivery to Activated Microglia/Macrophages in Spinal Cord Injury". Advanced Therapeutics 2200083

Product Used: AV034

Product Usage: Nanoparticle Shell

来源：https://www.amyjet.com/products/PST-AK054.shtml

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艾美捷PolySciTech PDLLA-PEG-Mal说明书

艾美捷PDLLA-PEG-Mal 相关参数：

中文名称：PDLLA-PEG-Mal/聚（D，L-丙交酯）-b-聚（乙二醇）-马来酰亚胺，（16000:5000 Da）

英文名字：PDLLA-PEG-Mal / Poly(D,L-lactide)-b-poly(ethylene glycol)-maleimide, (16,000:5,000 Da)

cat#PST-AI065

PDLLA-PEG-Mal 图例：

图：H-NMR Spectrum of Mal-PEG-PDLLA copolymers in CDCl3 (Varian Inova 500 MHz instrument), NMR of repeat units: EG-LA = 102*-175 (Mn EG-LA = 4494*-12,593

(*data provided by MFG)Mal-PEG-PDLA共聚物的H-NMR谱CDCl3（Varian Inova 500 MHz仪器），重复核磁共振单位：EG-LA=102*-175（锰EG-LA=4494*-12593）

PDLLA-PEG-Mal文献参考：

Albert, C., Bracaglia, L., Koide, A. et al. . "Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications". Nature Communications volume 13, Article number: 5998 (2022)

Product Used: AK054, AI030, AI065

Product Usage: Decorated Nanoparticle Shell

PDLLA-PEG-Mal其它研究：

AV011   聚（丙交酯-共乙克醇化物）-罗丹明 B PLGA

AV013   聚（L-乳酸）酸-FPR648

AV015   聚丙交酯-共乙交酯-火烈士福陆 FKR648 PLGA-FKR648

AV016   聚（D，L-丙交酯）-荧光素

AV017   甲氧基聚乙二醇-b-聚（D，L）乳酸-弗拉玛-福陆FKR648共聚物

AV018   甲氧基-聚乙二醇-b-聚（丙交酯-共乙交酯）-FKR560共聚物

AV019   甲氧基-聚乙二醇-b-聚（丙交酯-共乙醇化物）-FKB350共聚物

AV020   甲氧基-聚乙二醇-b-聚（丙交酯-共-乙交酯）-FKG456共聚物

AV021   甲氧基-聚乙二醇-b-聚（丙交酯-共乙交酯）-FKR560共聚物

来源：https://www.amyjet.com/products/PST-AI065.shtml

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艾美捷PolySciTech PLGA-PEG-Mal 参数说明

艾美捷PLGA-PEG-Mal 相关参数：

中文名称：PLGA-PEG-Mal/聚丙交酯-乙二醇-马来酰亚胺，LG 75:25（Mw ~ 60000:3400 Da）

英文名字：PLGA-PEG-Mal / Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-maleimide, LG 75:25 (Mw ~60,000:3,400 Da)

cat#PST-AI052

规格：100mg

PLGA-PEG-Mal 图例：

图：Analysis Method: Varian Prostar system with 1 ml/min DCM flow across two Phenogel 5u columns and one Resipore column (Agilent). Detection via UV/Vis, calibrated against polystyrene standards分析方法：Varian Prostar系统，DCM流速为1ml/min，流经两个Phenogel 5u柱和一个Resipore柱（Agilent）。通过UV/Vis检测，根据聚苯乙烯标准进行校准

PDLLA-PEG-Mal文献参考：

Wu, Bin. "Extremely small nanoparticles of degradable polymers". U.S. Patent Application 15/897,371, filed January 24, 2019

Product Used: AV017, AV018, AV016, AV013, AV015, AV001, AV006, AV011, AI016, AI025, AI096, AI052, AI078, AI087, AI021, AI086

Product Usage: Nanoparticle Shell

Min, Yuanzeng, Kyle C. Roche, Shaomin Tian, Michael J. Eblan, Karen P. McKinnon, Joseph M. Caster, Shengjie Chai et al.. "Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy". Nature Nanotechnology (2017)

Product Used: AP059, AK037, AI058, AI052, AV011

Product Usage: Nanoparticle Shell

Paka, Ghislain Djiokeng, and Charles Ramassamy. "Optimization of curcumin loaded-PEG-PLGA nanoparticles by GSH functionalization. Investigation of the internalization pathway in neuronal cells". Molecular Pharmaceutics

Product Used: AI052, AV011

Product Usage: Nanoparticle Shell

Piazza, Justin, Todd Hoare, Luke Molinaro, Kristen Terpstra, Jayant Bhandari, P. Ravi Selvaganapathy, Bhagwati Gupta, and Ram K. Mishra. "Haloperidol-loaded intranasally administered lectin functionalized poly (ethylene glycol)–block-poly (d, l)-lactic-co-glycolic acid (PEG–PLGA) nanoparticles for the treatment of schizophrenia". European Journal of Pharmaceutics and Biopharmaceutics 87, no. 1 (2014): 30-39

Product Used: AK029, AI052

Product Usage: Decorated Nanoparticle Shell

来源：https://www.amyjet.com/products/PST-AI052.shtml

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艾美捷PolySciTech PLGA-PEG-NH2解决方案

艾美捷PLGA-PEG-NH2相关参数：

中文名称：PLGA-PEG-NH2 / 聚（丙交酯-共-乙交酯）-b-聚（乙二醇）-胺封端，（Mw ~12,000:5,000 Da）

英文名字：PLGA-PEG-NH2 / Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-amine endcap, (Mw ~12,000:5,000 Da)

cat#PST-AI058

规格：100mg

 PLGA-PEG-NH2 图例：

图：H-NMR Spectrum of PLGA-PEG-NH2 copolymers in CDCl3 (Varian Inova 500 MHz instrument), NMR of PLGA-PEG-NH2 repeat units:EG-LA/GA = 103-80/74 (Mn: 4,538-5,728/4,319 Da) PLGA-PEG-NH2共聚物在CDCl3中的H-NMR谱（Varian Inova 500 MHz仪器），PLGA-PEG-NH2的NMR 重复单位：EG-LA/GA=103-80/74（Mn：4538-5728/4319 Da）

PLGA-PEG-NH2文献参考：

Granot, Z., Völs, S., Kaisar-Iluz, N., Shaul, M.E., Ryvkin, A., Ashkenazy, H., Yehuda, A., Atamneh, R., Meital, B.D.N., Nadav, M. and Hirsch, S.. "Targeted Nanoparticles Modify Neutrophil Function In Vivo". Frontiers in Immunology p.5679.

Product Used: AV034, AI110

Product Usage: Decorated Nanoparticle Shell

Hirsch, S., Hinden, L., Naim, M.B.D., Baraghithy, S., Permyakova, A., Azar, S., Nasser, T., Portnoy, E., Agbaria, M., Nemirovski, A. and Golomb, G.. "Hepatic targeting of the centrally active cannabinoid 1 receptor (CB1R) blocker rimonabant via PLGA nanoparticles for treating fatty liver disease and diabetes". Journal of Controlled Release 353, pp.254-269.

Product Used: AV034

Product Usage: Nanoparticle Shell

Lamson, Nicholas G., Andrew J. Pickering, Jeffrey Wyckoff, Priya Ganesh, Joelle P. Straehla, and Paula T. Hammond. "Core material and surface chemistry of Layer-by-Layer (LbL) nanoparticles independently direct uptake, transport, and trafficking in preclinical blood-brain barrier (BBB) models". bioRxiv (2022)

Product Used: AV034

Product Usage: Nanoparticle Shell

Piotrowski-Daspit, A.S., Barone, C., Lin, C.Y., Deng, Y., Wu, D., Binns, T.C., Xu, E., Ricciardi, A.S., Putman, R., Garrison, A. and Nguyen, R.. "In vivo correction of cystic fibrosis mediated by PNA nanoparticles". Science Advances 8(40), p.eabo0522.

Product Used: AV034

Product Usage: Nanoparticle Shell

Stigliano, Cinzia, Allison Frazier, and Philip J. Horner. "Modulation of Neuroinflammation Via Selective Nanoparticle‐Mediated Drug Delivery to Activated Microglia/Macrophages in Spinal Cord Injury". Advanced Therapeutics 2200083

Product Used: AV034

Product Usage: Nanoparticle Shell

来源：https://www.amyjet.com/products/PST-AI058.shtml