来宝网Logo

热门词:生物显微镜 水质分析仪 微波消解 荧光定量PCR 电化学工作站 生物安全柜

现在位置首页>技术资料首页>行业动态>公司动态>罗氏收购基因组工具提供商Kapa Biosystems

罗氏收购基因组工具提供商Kapa Biosystems

互联网2015年8月21日 10:35 点击:1271

瑞士罗氏Roche  美国Kapa Biosystems

    2015年8月20日,罗氏集团旗下分为制药和诊断两大业务部门,在过去的2年里,罗氏控股在诊断和药物开发方面投入较多,还有一系列集中在抗生素领域的小收购。上周,罗氏宣布以超过4.25亿美元的价格收购GeneWEAVE生物科技公司,后者是一家微生物公司,罗氏收购其旨在快速地发展鉴别耐药性细菌技术。
 

罗氏收购Kapa Biosystems,继续巩固NGS技术
 

8月19日,罗氏控股宣布收购基因科技公司Kapa Biosystems,后者是一家新兴的生物公司,主要业务集中在基因组研究,单细胞DNA的测序以及肿瘤基因突变的个体化医疗;主要为生命科学领域提供基因组工具,采用独有的技术对酶进行优化,用于新一代测序技术(NGS),聚合酶链反应(PCR)和实时PCR应用。不过在这项收购中,具体的财务细节暂未透露。

罗氏收购Kapa时表示,后者专有的直接分子进化平台是一种高度可定制的蛋白质工程技术,能够产生并筛查大量的酶突变体,可为特定的应用量身定制高性能的生物酶,加速相关产品的开发进度。该公司令人印象深刻的NGS试剂组合包括各种酶,例如新颖的DNA聚合酶,有望提高整个测序工作流程的性能。收购Kapa是建立在罗氏致力于开发一种差异化NGS产品组合的战略之上,意在为其客户提供一套完整的基因检测解决方案。Kapa公司的技术和产品与罗氏当前的专业知识和产品具有互补性,将增强罗氏NGS产品组合并有助于罗氏在NGS领域的扩张。

其实自2013年以来,罗氏就与Kapa一直保持着合作,双方在去年底扩大合作关系,Kapa同意为罗氏旗下NimbleGen单元开发及生产定制的RNA测序样品制备试剂盒。现在,罗氏决定收购Kapa,加强下一代测序(NGS)产品资产。

罗氏——肿瘤免疫疗法的领先者

罗氏还在肿瘤市场具有领先地位,尤其是在肿瘤免疫疗法的研发方面。

肿瘤免疫是运用生物技术和生物制剂对从病人体内采集的免疫细胞进行体外培养和扩增后回输到病人体内的方法,来增强机体自身免疫功能,从而达到治疗肿瘤的目的。肿瘤免疫疗法是继手术、放疗和化疗之后的第四大肿瘤治疗技术,并将成为未来癌症治疗领域的“明星”方法。根据高盛咨询(Goldman Sachs)的数据,到2025年,肿瘤免疫疗法的市场预计达350亿美元。

在罗氏最受期待的肿瘤免疫产品,莫过于正在试验的PD-L1抑制剂药物——atezolizumab。目前市场上已经批准的PD-1抑制剂可以刺激免疫系统对肿瘤的反应。在未来,atezolizumab或将成为肿瘤免疫市场最大的一块蛋糕。

最近,罗氏报道了atezolizumab在治疗非小细胞肺癌患者(NSCLC)的积极临床试验结果,能够作用85%的肺癌患者。FDA已经将这项疗法定义为治疗非小细胞肺癌和膀胱癌的突破性疗法,除此之外,该药物还正在积极开展另外7种癌症适应症的治疗评价。罗氏也正在将这些疗法与传统的抗癌药进行对比性试验。例如,罗氏的鸡尾酒疗法药物赫赛汀(Herceptin)和Perjeta被用来治疗转移性乳腺癌,赫赛汀已经成为扬名天下的重磅弹药。


 

罗氏在肿瘤免疫疗法领域的pipeline

除此之外,罗氏还在加速一些治疗血癌的药物研究,例如venetoclax(ABT-199)在治疗慢性淋巴细胞白血病的二期临床试验结果较好。Venetoclax也已经被认定为突破性疗法药物,这是罗氏和艾伯维公司共同开发的。罗氏在2015年的第二季度还获得了系统性硬化病试验药物Actemra/RoActemra的突破性疗法地位。

除此之外,FDA还将继续加速对新型抗癌药的审批工作,罗氏已经占据了肿瘤市场的60%的市场,成为全球抗癌药的领衔者。

彭博社智库分析专家认为,到2020年,罗氏的抗癌药将卖到300亿美元。在2015年,罗氏预计整体营收将会下降到个位数,但是核心业务盈利增长速度将超过收入。

Roche to acquire Kapa Biosystems to strengthen next-generation sequencing product offerings

Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that it has signed a definitive agreement to acquire Kapa Biosystems, Inc. (Kapa) a privately-held company headquartered in Wilmington, Massachusetts, US. Kapa Biosystems is a provider of genomic tools in the life sciences sector that employs proprietary technologies to optimize enzymes for next-generation sequencing (NGS), as well as polymerase chain reaction (PCR) and real-time PCR applications¹.

Kapa’s proprietary protein engineering technology is highly customizable and allows for the generation and screening of large numbers of enzyme variants. Tailored enzymes with improved performance for specific applications can be rapidly selected, expediting product development timelines. Kapa’s impressive portfolio of NGS reagents includes enzymes such as novel DNA polymerases, with the potential to improve the performance of the entire sequencing workflow.

“This acquisition builds on Roche’s commitment to develop a differentiated NGS portfolio that will provide our customers with a complete genetic testing solution,” said Roland Diggelmann, COO Roche Diagnostics Division. “Kapa’s technology and products complement our current expertise and offerings such as the portfolio of target enrichment products for NGS. We welcome Kapa’s employees and are looking forward to strengthening our NGS offerings with this unique technology.”

“Joining Roche provides us access to their broad product portfolio, global reach and clinical expertise that will accelerate our strategy of offering comprehensive NGS workflow solutions to more laboratories around the world,” said Paul McEwan, Co-Founder and Chief Scientific Officer of Kapa Biosystems. “We are also excited to have the opportunity to further leverage our enzyme engineering capabilities to advance the fields of genomics and sequencing, with the ultimate goal of having a more significant impact on medicine and human health.”

The transaction is subject to customary closing conditions. Financial terms of the transaction are not disclosed.

About Kapa Biosystems

Kapa Biosystems, co-founded by Trey Foskett, Paul McEwan, Ron McEwan and Chris McGuinness in 2006, has pioneered the use of directed evolution to develop a suite of high-performance reagents for a range of life science applications. Their products are used by thousands of scientists around the world and cited in more than 4,000 peer-reviewed publications. They are continuing to develop innovative solutions that accelerate genomics research that can impact the future ability to diagnose, monitor and treat cancer and complex inherited and infectious diseases.

Kapa Biosystems is based in Wilmington, Massachusetts, and has a research, development and manufacturing facility in Cape Town, South Africa.

For more information, visit http://www.kapabiosystems.com/

About Roche

Headquartered in Basel, Switzerland, Roche is a leader in research-focused healthcare with combined strengths in pharmaceuticals and diagnostics. Roche is the world’s largest biotech company, with truly differentiated medicines in oncology, immunology, infectious diseases, ophthalmology and neuroscience. Roche is also the world leader in in vitro diagnostics and tissue-based cancer diagnostics, and a frontrunner in diabetes management. Roche’s personalised healthcare strategy aims at providing medicines and diagnostics that enable tangible improvements in the health, quality of life and survival of patients. Founded in 1896, Roche has been making important contributions to global health for more than a century. Twenty-nine medicines developed by Roche are included in the World Health Organization Model Lists of Essential Medicines, among them life-saving antibiotics, antimalarials and chemotherapy.

In 2014, the Roche Group employed 88,500 people worldwide, invested 8.9 billion Swiss francs in R&D and posted sales of 47.5 billion Swiss francs. Genentech, in the United States, is a wholly owned member of the Roche Group. Roche is the majority shareholder in Chugai Pharmaceutical, Japan. For more information, please visit roche.com.

All trademarks used or mentioned in this release are protected by law.

(来源: 互联网 )


全年征稿 / 资讯合作

联系邮箱:kefu@labbase.net

版权与免责声明

  • 凡本网注明“来源:来宝网”的所有作品,版权均属于来宝网,转载请必须注明来宝网, //www.next-search.com,违反者本网将追究相关法律责任。
  • 本网转载并注明自其它来源的作品,目的在于传递更多信息,并不代表本网赞同其观点或证实其内容的真实性,不承担此类作品侵权行为的直接责任及连带责任。其他媒体、网站或个人从本网转载时,必须保留本网注明的作品来源,并自负版权等法律责任。
  • 如涉及作品内容、版权等问题,请在作品发表之日起一周内与本网联系,否则视为放弃相关权利。